Ontology highlight
ABSTRACT:
SUBMITTER: Ciampi R
PROVIDER: S-EPMC6817656 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Ciampi Raffaele R Romei Cristina C Ramone Teresa T Prete Alessandro A Tacito Alessia A Cappagli Virginia V Bottici Valeria V Viola David D Torregrossa Liborio L Ugolini Clara C Basolo Fulvio F Elisei Rossella R
iScience 20190926
Sporadic Medullary Thyroid Carcinoma (sMTC) is a rare but aggressive thyroid tumor. RET and RAS genes are present in about 50%-80% of cases, but most of the remaining cases are still orphan of a genetic driver. We studied the largest series of sMTC by deep sequencing to define the mutational landscape. With this methodology we greatly reduced the number of RET- or RAS-negative cases and we confirmed the central role of RET and RAS mutations. Moreover, we highlighted the bad prognostic role of RE ...[more]