Ontology highlight
ABSTRACT:
SUBMITTER: Vassaux M
PROVIDER: S-EPMC6818171 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Vassaux Maxime M Pieuchot Laurent L Anselme Karine K Bigerelle Maxence M Milan Jean-Louis JL
Biophysical journal 20190722 6
The latest experiments have shown that adherent cells can migrate according to cell-scale curvature variations via a process called curvotaxis. Despite identification of key cellular factors, a clear understanding of the mechanism is lacking. We employ a mechanical model featuring a detailed description of the cytoskeleton filament networks, the viscous cytosol, the cell adhesion dynamics, and the nucleus. We simulate cell adhesion and migration on sinusoidal substrates. We show that cell adhesi ...[more]