Ontology highlight
ABSTRACT:
SUBMITTER: Pieuchot L
PROVIDER: S-EPMC6162274 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Pieuchot Laurent L Marteau Julie J Guignandon Alain A Dos Santos Thomas T Brigaud Isabelle I Chauvy Pierre-François PF Cloatre Thomas T Ponche Arnaud A Petithory Tatiana T Rougerie Pablo P Vassaux Maxime M Milan Jean-Louis JL Tusamda Wakhloo Nayana N Spangenberg Arnaud A Bigerelle Maxence M Anselme Karine K
Nature communications 20180928 1
Cells have evolved multiple mechanisms to apprehend and adapt finely to their environment. Here we report a new cellular ability, which we term "curvotaxis" that enables the cells to respond to cell-scale curvature variations, a ubiquitous trait of cellular biotopes. We develop ultra-smooth sinusoidal surfaces presenting modulations of curvature in all directions, and monitor cell behavior on these topographic landscapes. We show that adherent cells avoid convex regions during their migration an ...[more]