Ontology highlight
ABSTRACT:
SUBMITTER: Patil M
PROVIDER: S-EPMC6818331 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Patil Mayur M Belugin Sergei S Mecklenburg Jennifer J Wangzhou Andi A Paige Candler C Barba-Escobedo Priscilla A PA Boyd Jacob T JT Goffin Vincent V Grattan David D Boehm Ulrich U Dussor Gregory G Price Theodore J TJ Akopian Armen N AN
iScience 20191001
Many clinical and preclinical studies report an increased prevalence and severity of chronic pain among females. Here, we identify a sex-hormone-controlled target and mechanism that regulates dimorphic pain responses. Prolactin (PRL), which is involved in many physiologic functions, induces female-specific hyperalgesia. A PRL receptor (Prlr) antagonist in the hind paw or spinal cord substantially reduced hyperalgesia in inflammatory models. This effect was mimicked by sensory neuronal ablation o ...[more]