Dataset Information

Prevalence of food-allergen and aeroallergen sensitization among people in Sichuan, Western China: An 8-year observational study.

ABSTRACT:

Background

Identifying the distribution of allergens is invaluable to effective diagnosis and treatment of allergic disease. The present study aims to analyze the epidemiology of allergens in Sichuan, Western China.

Methods

A total of 14 030 participants including 8031 men and 5999 women were enrolled in this study during 2007-2014 in West China Hospital. An assay testing for the presence of allergen-specific IgE was used to identify highly immunogenic allergens.

Results

Of the 14 030 total participants, 3470 (24.72%) were sensitive to at least one of tested allergens. The most immunogenic allergens were mite mix (1876, 13.38%), crab (876, 6.24%), sea-fish mix (865, 6.16%), house dust (355, 2.54%), and cockroach (292, 2.08%). The differences between population of participants who were sensitive to food allergens and aeroallergens were statistically significant in 0 to 10, 11 to 20, 21 to 30, 41 to 50, and 51 to 60 year-old age-groups (all P < 0.05). Distributions of three food allergens and two aeroallergens were significantly different between male and female participants. There was also an increase in sensitization to cow's milk, mutton, sea-fish, and mould that was observed in the 71 to 90 year-old group.

Conclusion

The most common allergens presented in Sichuan were observed to be mites, crab, sea-fish, and house dust. There was an observable difference in sensitivity to five allergens between males and females. Additionally, aeroallergens appeared to have a greater immunogenic effect in younger populations while the elderly presented with increased sensitization to specific allergens, suggesting that specific allergens' immunogenicity was age-dependent.

SUBMITTER: Huang Z

PROVIDER: S-EPMC6818623 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Prevalence of food-allergen and aeroallergen sensitization among people in Sichuan, Western China: An 8-year observational study.

Huang Zhuochun Z Feng Weihua W Wei Wei W Yang Bin B Wang Lanlan L

Journal of clinical laboratory analysis 20181121 3

<h4>Background</h4>Identifying the distribution of allergens is invaluable to effective diagnosis and treatment of allergic disease. The present study aims to analyze the epidemiology of allergens in Sichuan, Western China.<h4>Methods</h4>A total of 14 030 participants including 8031 men and 5999 women were enrolled in this study during 2007-2014 in West China Hospital. An assay testing for the presence of allergen-specific IgE was used to identify highly immunogenic allergens.<h4>Results</h4>Of ...[more]

PMID: 30461057

Similar Datasets

Project description:BackgroundHousehold endotoxin levels have been variably associated with risk for asthma and atopy.MethodsWe studied participants from the 2005-2006 National Health and Nutrition Examination Survey (NHANES, n = 6963), a large cohort representative of the US population (aged 1-84 years). We built logistic regression models to test for associations between house dust endotoxin and sensitization to specific foods (milk, egg, and peanut). To experimentally explore the detected epidemiologic associations, peripheral blood mononuclear cells (PBMCs) were collected from 21 children (aged 1-19 years) mono-food allergic (ie, sensitized and clinically reactive) to milk, egg, or peanut and nonallergic controls for stimulation with endotoxin and secreted cytokine measurement. For each food allergy, linear mixed-effects models were built to test the association between endotoxin stimulation and cytokine level.ResultsAmong NHANES subjects, the geometric mean household endotoxin level was 15.5 EU/mg (GSE 0.5). Prevalence of food allergen sensitization (sIgE ≥ 0.35 kUA /L) varied by food: milk 5.7%, egg 4.0%, and peanut 7.9%. In models adjusted for potential confounders (age, race, country of birth, total people per household, US region, and history of wheezing in the past year), household endotoxin level was associated with sensitization to milk (OR 1.7, 95% CI 1.2-2.1) and egg (OR 1.4, 95% CI 1.01-1.9), but not peanut (OR 0.98, 95% CI 0.8-1.2). Interferon-γ levels of endotoxin-stimulated PBMCs from children allergic to milk or egg, but not peanut, were significantly lower compared to controls in linear mixed-effects models adjusted for repeated measures, experimental variables, age, and inter-individual variability (P-values .007, .018, and .058, respectively).ConclusionHigher household endotoxin is associated with increased odds of milk and egg sensitization. Altered cytokine responsiveness to endotoxin is also observed in PBMCs from individuals with milk and egg allergy.

Dataset Information

Prevalence of food-allergen and aeroallergen sensitization among people in Sichuan, Western China: An 8-year observational study.

Background

Methods

Results

Conclusion

Publications

Prevalence of food-allergen and aeroallergen sensitization among people in Sichuan, Western China: An 8-year observational study.

Similar Datasets

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