Ontology highlight
ABSTRACT:
SUBMITTER: Gondek LP
PROVIDER: S-EPMC6819101 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20191101 11
The interleukin 3 receptor (CD123) is a transmembrane protein that is absent or hardly expressed on normal hematopoietic stem cells, but highly expressed on the surface of cancer cells in several hematologic malignancies. In this issue of the JCI, Togami et al. investigated the mechanism of resistance to the recently approved anti-CD123 agent tagraxofusp, which consists of interleukin 3 fused to a truncated diphtheria toxin (DT) molecule. The authors demonstrated that loss of the intracellular t ...[more]