Analysis of prognosis, genome, microbiome, and microbial metabolome in different sites of colorectal cancer.

ABSTRACT:

Background

The colorectum includes ascending colon, transverse colon, descending colon, sigmoid colon, and rectum. Different sites of colorectal cancer (CRC) are different in many aspects, including clinical symptoms, biological behaviour, and prognosis.

Purpose

This study aimed to analyse prognosis, genes, bacteria, fungi, and microbial metabolome in different sites of CRC.

Methods

The Surveillance, Epidemiology, and End Results (SEER) database and STAT were used to statistically describe and analyse the prognosis in different sites of CRC. RNA sequences of CRC from Broad Institute's GDAC Firehose were re-annotated and reanalysed based on different sites using weighted gene co-expression network analysis (WGCNA). The Kaplan-Meier method was used to analyse the progno

SUBMITTER: Xi Y 

PROVIDER: S-EPMC6819376 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature