Ontology highlight
ABSTRACT:
SUBMITTER: Gatti-Mays ME
PROVIDER: S-EPMC6820540 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Gatti-Mays Margaret E ME Balko Justin M JM Gameiro Sofia R SR Bear Harry D HD Prabhakaran Sangeetha S Fukui Jami J Disis Mary L ML Nanda Rita R Gulley James L JL Kalinsky Kevin K Abdul Sater Houssein H Sparano Joseph A JA Cescon David D Page David B DB McArthur Heather H Adams Sylvia S Mittendorf Elizabeth A EA
NPJ breast cancer 20191029
Historically, breast cancer tumors have been considered immunologically quiescent, with the majority of tumors demonstrating low lymphocyte infiltration, low mutational burden, and modest objective response rates to anti-PD-1/PD-L1 monotherapy. Tumor and immunologic profiling has shed light on potential mechanisms of immune evasion in breast cancer, as well as unique aspects of the tumor microenvironment (TME). These include elements associated with antigen processing and presentation as well as ...[more]