Ontology highlight
ABSTRACT:
SUBMITTER: Elko EA
PROVIDER: S-EPMC6820706 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Elko Evan A EA Mahoney J Matthew JM Vacek Pamela P van der Vliet Albert A Anathy Vikas V van der Velden Jos L J L JLJL Janssen-Heininger Yvonne M W YMW Seward David J DJ
Free radical biology & medicine 20190714
Aging is associated with enhanced oxidative stress and increased susceptibility to numerous diseases. This relationship is particularly striking with respect to the incidence of fibrotic lung disease. To identify potential mechanisms underlying the association between aging and susceptibility to fibrotic lung disease we analyzed transcriptome data from 342 disease-free human lung samples as a function of donor age. Our analysis reveals that aging in lung is accompanied by modest yet progressive ...[more]