Dataset Information

Associations of early life and adulthood adiposity with risk of epithelial ovarian cancer.

ABSTRACT:

Background

Few studies have evaluated the association between early life adiposity and ovarian cancer risk. Adiposity during different periods of life may be differentially associated with the risk.

Patients and methods

We prospectively followed 133 526 women in the Nurses' Health Study (NHS; 1980-2012) and NHSII (1989-2013). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident ovarian cancer (N?=?788) according to validated measures for early life adiposity [body mass index (BMI) at age 10 imputed from somatotype and recalled BMI at age 18) as well as BMI change between age 10 and 18 and after age 18 (current weight assessed on every biennial questionnaire since baseline).

Results

After mutual adjustment for BMI at age 10, BMI at age 18 and current BMI, the HR (95% CI) for ovarian cancer risk per 5?kg/m2 was 0.84 (0.74-0.96) for BMI at age 10 (P-trend?=?0.01), 1.17 (1.03-1.33) for BMI at age 18 (P-trend?=?0.02), and 1.06 (0.99-1.14) for current BMI (P-trend?=?0.08). However, the inverse association with BMI at age 10 was attenuated after adjusting for BMI change between age 10 and 18 and BMI change after age 18 (HR per 5?kg/m2: 1.04; 95% CI 0.91-1.20; P-trend?=?0.55). By contrast, BMI change between age 10 and 18 was strongly positively associated with ovarian cancer risk (HR per 5?kg/m2 increase: 1.24; 95% CI 1.11-1.39; P-trend?=?0.0002), whereas BMI change since age 18 was only slightly associated with risk (HR per 5?kg/m2 increase: 1.06; 95% CI 0.99-1.14; P-trend?=?0.10). These associations were in general stronger for premenopausal cases or non-serous tumors.

Conclusion

Early life changes in adiposity were more strongly associated with ovarian cancer risk than adulthood changes. The specific mechanisms underlying the associations with adiposity changes during early life warrant further investigation.

SUBMITTER: Huang T

PROVIDER: S-EPMC6821311 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Associations of early life and adulthood adiposity with risk of epithelial ovarian cancer.

Huang T T Tworoger S S SS Willett W C WC Stampfer M J MJ Rosner B A BA

Annals of oncology : official journal of the European Society for Medical Oncology 20190201 2

<h4>Background</h4>Few studies have evaluated the association between early life adiposity and ovarian cancer risk. Adiposity during different periods of life may be differentially associated with the risk.<h4>Patients and methods</h4>We prospectively followed 133 526 women in the Nurses' Health Study (NHS; 1980-2012) and NHSII (1989-2013). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident ovarian cancer (N = 788) according ...[more]

PMID: 30576422

Similar Datasets

Project description:ObjectiveThis study aimed to investigate directional influences in the association between adiposity and physical activity (PA) from pre-puberty to early adulthood.MethodsIn the Calex-study, height, weight, body fat and leisure-time physical activity (LTPA) were measured at age11.2-years, 13.2-years and 18.3-years in 396 Finnish girls. Body fat was measured by dual-energy X-ray absorptiometry, calculating fat mass index (FMI) as total fat mass in kilograms divided by height in meters squared. LTPA level was evaluated using a physical activity questionnaire. In the European Youth Heart Study (EYHS), height, weight and habitual PA were measured at age 9.6-years, 15.7-years and 21.8-years in 399 Danish boys and girls. Habitual PA and sedentary behaviour were assessed with an accelerometer. Directional influences of adiposity and PA were examined using a bivariate cross-lagged path panel model.ResultsThe temporal stability of BMI from pre-puberty to early adulthood was higher than the temporal stability of PA or physical inactivity over the same time period both in girls and boys. In the Calex-study, BMI and FMI at age 11.2-years were both directly associated with LTPA at age 13.2-years (β = 0.167, p = 0.005 and β = 0.167, p = 0.005, respectively), whereas FMI at age 13.2-years showed an inverse association with LTPA at age 18.3-years (β = - 0.187, p = 0.048). However, earlier LTPA level was not associated with subsequent BMI or FMI. In the EYHS, no directional association was found for physical inactivity, light-, moderate-, and vigorous-PA with BMI during the follow-up in girls. In boys, BMI at age 15.7-years was directly associated with moderate PA (β = 0.301, p = 0.017) at age 21.8-years, while vigorous PA at age 15.7-years showed inverse associations with BMI at age 21.8-years (β = - 0.185, p = 0.023).ConclusionOur study indicates that previous fatness level is a much stronger predictor of future fatness than level of leisure-time or habitual physical activity during adolescence. The directional associations between adiposity and physical activity are not clear during adolescence, and may differ between boys and girls depending on pubertal status.

Dataset Information

Associations of early life and adulthood adiposity with risk of epithelial ovarian cancer.

Background

Patients and methods

Results

Conclusion

Publications

Associations of early life and adulthood adiposity with risk of epithelial ovarian cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets