Ontology highlight
ABSTRACT:
SUBMITTER: Tabata E
PROVIDER: S-EPMC6821832 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Tabata Eri E Wakita Satoshi S Kashimura Akinori A Sugahara Yasusato Y Matoska Vaclav V Bauer Peter O PO Oyama Fumitaka F
Scientific reports 20191030 1
Commercially available porcine pepsin preparations have been used for the production of chitooligosaccharides with various biomedical activities. However, the origin of this activity is not well understood. Here we show that the chitosan-degrading activity is conferred by residues with chitinolytic activity of truncated forms of acidic chitinase (Chia) persisting in the pepsin preparation. Chia is an acid-stable and pepsin-resistant enzyme that degrades chitin to produce N-acetyl-D-glucosamine d ...[more]