Ontology highlight
ABSTRACT:
SUBMITTER: Zhu C
PROVIDER: S-EPMC6822168 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Zhu Changyu C Kim KyeongJin K Wang Xiaobo X Bartolome Alberto A Salomao Marcela M Dongiovanni Paola P Meroni Marica M Graham Mark J MJ Yates Katherine P KP Diehl Anna Mae AM Schwabe Robert F RF Tabas Ira I Valenti Luca L Lavine Joel E JE Pajvani Utpal B UB
Science translational medicine 20181101 468
Fibrosis is the major determinant of morbidity and mortality in patients with nonalcoholic steatohepatitis (NASH) but has no approved pharmacotherapy in part because of incomplete understanding of its pathogenic mechanisms. Here, we report that hepatocyte Notch activity tracks with disease severity and treatment response in patients with NASH and is similarly increased in a mouse model of diet-induced NASH and liver fibrosis. Hepatocyte-specific Notch loss-of-function mouse models showed attenua ...[more]