Ontology highlight
ABSTRACT:
SUBMITTER: Itoh M
PROVIDER: S-EPMC5752377 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Itoh Michiko M Suganami Takayoshi T Kato Hideaki H Kanai Sayaka S Shirakawa Ibuki I Sakai Takeru T Goto Toshihiro T Asakawa Masahiro M Hidaka Isao I Sakugawa Hiroshi H Ohnishi Koji K Komohara Yoshihiro Y Asano Kenichi K Sakaida Isao I Tanaka Masato M Ogawa Yoshihiro Y
JCI insight 20171116 22
Although recent evidence has pointed to the role of organ- and pathogenesis-specific macrophage subsets, it is still unclear which subsets are critically involved in the pathogenesis of nonalcoholic steatohepatitis (NASH). Using melanocortin-4 receptor-deficient (MC4R-KO) mice fed Western diet (WD), which exhibit liver phenotypes similar to those of human NASH, we found a histological structure, termed hepatic crown-like structure (hCLS), in which CD11c+ macrophages surround dead/dying hepatocyt ...[more]