Ontology highlight
ABSTRACT:
SUBMITTER: Zhu T
PROVIDER: S-EPMC6822491 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhu Texuan T Chen Jingfei J Zhao Yanhua Y Zhang Jiejie J Peng Qiaozhen Q Huang Jingrui J Luo Jiefeng J Zhang Weishe W
Bioscience reports 20191001 10
Neuromedin B (NMB) and its receptor regulate labor onset by mediating inflammatory factors; however the underlying mechanisms remain poorly understood. The present study is aimed to investigate the mechanisms of NMB-induced cyclo-oxygenase 2 (COX-2) expression and interleukin (IL)-6 generation in human primary myometrial cells. The results indicated that NMB could increase phosphorylation of nuclear factor κB (NF-κB) transcription factor p65 (p65) and Jun proto-oncogene, activator protein 1 (AP- ...[more]