Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Z
PROVIDER: S-EPMC6822493 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Jiang Zongzhe Z Wan Shengrong S Xing Bowen B
Bioscience reports 20191001 10
Menin is encoded by multiple endocrine neoplasia type 1 (MEN1) gene, the germ line mutations of which are the main cause of pancreatic neuroendocrine tumors (PNETs). To date, a large number of frameshift, nonsense and missense mutations of MEN1 have been identified to be responsible for part of MEN1-defficient PNETs patients due to truncation or rapid degradation of menin protein. However, the stability of the wild-type (WT) menin in PNETs is totally unknown. In the present study, we observed ub ...[more]