Ontology highlight
ABSTRACT:
SUBMITTER: Croce G
PROVIDER: S-EPMC6822775 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Croce Giancarlo G Gueudré Thomas T Ruiz Cuevas Maria Virginia MV Keidel Victoria V Figliuzzi Matteo M Szurmant Hendrik H Weigt Martin M
PLoS computational biology 20191021 10
Interacting proteins and protein domains coevolve on multiple scales, from their correlated presence across species, to correlations in amino-acid usage. Genomic databases provide rapidly growing data for variability in genomic protein content and in protein sequences, calling for computational predictions of unknown interactions. We first introduce the concept of direct phyletic couplings, based on global statistical models of phylogenetic profiles. They strongly increase the accuracy of predic ...[more]