Common brain disorders are associated with heritable patterns of apparent aging of the brain.
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ABSTRACT:
SUBMITTER: Kaufmann T
PROVIDER: S-EPMC6823048 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Common brain disorders are associated with heritable patterns of apparent aging of the brain.
Kaufmann Tobias T van der Meer Dennis D Doan Nhat Trung NT Schwarz Emanuel E Lund Martina J MJ Agartz Ingrid I Alnæs Dag D Barch Deanna M DM Baur-Streubel Ramona R Bertolino Alessandro A Bettella Francesco F Beyer Mona K MK Bøen Erlend E Borgwardt Stefan S Brandt Christine L CL Buitelaar Jan J Celius Elisabeth G EG Cervenka Simon S Conzelmann Annette A Córdova-Palomera Aldo A Dale Anders M AM de Quervain Dominique J F DJF Di Carlo Pasquale P Djurovic Srdjan S Dørum Erlend S ES Eisenacher Sarah S Elvsåshagen Torbjørn T Espeseth Thomas T Fatouros-Bergman Helena H Flyckt Lena L Franke Barbara B Frei Oleksandr O Haatveit Beathe B Håberg Asta K AK Harbo Hanne F HF Hartman Catharina A CA Heslenfeld Dirk D Hoekstra Pieter J PJ Høgestøl Einar A EA Jernigan Terry L TL Jonassen Rune R Jönsson Erik G EG Kirsch Peter P Kłoszewska Iwona I Kolskår Knut K KK Landrø Nils Inge NI Le Hellard Stephanie S Lesch Klaus-Peter KP Lovestone Simon S Lundervold Arvid A Lundervold Astri J AJ Maglanoc Luigi A LA Malt Ulrik F UF Mecocci Patrizia P Melle Ingrid I Meyer-Lindenberg Andreas A Moberget Torgeir T Norbom Linn B LB Nordvik Jan Egil JE Nyberg Lars L Oosterlaan Jaap J Papalino Marco M Papassotiropoulos Andreas A Pauli Paul P Pergola Giulio G Persson Karin K Richard Geneviève G Rokicki Jaroslav J Sanders Anne-Marthe AM Selbæk Geir G Shadrin Alexey A AA Smeland Olav B OB Soininen Hilkka H Sowa Piotr P Steen Vidar M VM Tsolaki Magda M Ulrichsen Kristine M KM Vellas Bruno B Wang Lei L Westman Eric E Ziegler Georg C GC Zink Mathias M Andreassen Ole A OA Westlye Lars T LT
Nature neuroscience 20190924 10
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders. ...[more]
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