Ontology highlight
ABSTRACT:
SUBMITTER: Wachowius F
PROVIDER: S-EPMC6823052 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Wachowius Falk F Holliger Philipp P
ChemSystemsChem 20190220 1-2
Central to the "RNA world" hypothesis of the origin of life is the emergence of an RNA catalyst capable of RNA replication. However, possible replicase ribozymes are quite complex and were likely predated by simpler non-enzymatic replication reactions. The templated polymerisation of phosphorimidazolide (Imp) activated ribonucleotides currently appears as the most tractable route to both generate and replicate short RNA oligomer pools from which a replicase could emerge. Herein we demonstrate th ...[more]