Ontology highlight
ABSTRACT:
SUBMITTER: Buss F
PROVIDER: S-EPMC125554 | biostudies-literature | 2001 Jul
REPOSITORIES: biostudies-literature
Buss F F Arden S D SD Lindsay M M Luzio J P JP Kendrick-Jones J J
The EMBO journal 20010701 14
Myosin VI is involved in membrane traffic and dynamics and is the only myosin known to move towards the minus end of actin filaments. Splice variants of myosin VI with a large insert in the tail domain were specifically expressed in polarized cells containing microvilli. In these polarized cells, endogenous myosin VI containing the large insert was concentrated at the apical domain co-localizing with clathrin- coated pits/vesicles. Using full-length myosin VI and deletion mutants tagged with gre ...[more]