Ontology highlight
ABSTRACT:
SUBMITTER: Staquicini DI
PROVIDER: S-EPMC6824482 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
The pharmacogenomics journal 20171205 3
Translation of drug candidates into clinical settings requires demonstration of preclinical efficacy and formal toxicology analysis for filling an Investigational New Drug (IND) application with the US Food and Drug Administration (FDA). Here, we investigate the membrane-associated glucose response protein 78 (GRP78) as a therapeutic target in leukemia and lymphoma. We evaluated the efficacy of the GRP78-targeted proapoptotic drug bone metastasis targeting peptidomimetic 78 (BMTP-78), a member o ...[more]