?-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population.

ABSTRACT: Increasing studies demonstrated that genetic susceptibility attributes to the development of gestational diabetes mellitus (GDM). The polymorphisms of the ?-3 adrenergic receptor(?-3AR) gene have been found to be of great importance in bodyweight elevation and dyslipidaemias. We aimed to determine the influence of ?-3AR polymorphisms on the GDM risk. Thus, we performed a case-control study including 136 GDM cases and 138 controls to evaluate the relation between the rs201607471 and susceptibility to GDM. Likelihood ratios X analysis showed the distribution of the genotype frequency (rs201607471 in ?-3AR gene) was accorded with the Hardy-Weinberg genetic equilibrium. Although no significant association between rs201607471 alleles and GDM susceptibility (Chi-square test, P?>?.05), we observed that ?-3AR gene rs201607471 CT genotype was significantly prevalent in GDM (Chi-square test, P??T was significantly associated with an increased risk of GDM using the recessive model (CC vs CT/TT: P?=?.026) and the additive model (CC vs CT vs TT: P?=?.038). These data indicate that ?-3AR rs201607471 may be a helpful susceptibility marker for GDM in Chinese pregnant women.

SUBMITTER: Jia H 

PROVIDER: S-EPMC6824659 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature