Nanotherapy Targeting NF-?B Attenuates Acute Pain After Joint Injury.
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ABSTRACT:
SUBMITTER: Yan H
PROVIDER: S-EPMC6824724 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury.
Yan Huimin H Duan Xin X Collins Kelsey H KH Springer Luke E LE Guilak Farshid F Wickline Samuel A SA Rai M Farooq MF Pan Hua H Pham Christine T N CTN
Precision nanomedicine 20190112 1
Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis <i>in vivo</i>. Herein, we demonstrate that the suppression of NF-κB p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF ...[more]
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