The role of ligand-gated conformational changes in enzyme catalysis.
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ABSTRACT:
SUBMITTER: Moreira C
PROVIDER: S-EPMC6824834 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
The role of ligand-gated conformational changes in enzyme catalysis.
Moreira Cátia C Calixto Ana Rita AR Richard John P JP Kamerlin Shina Caroline Lynn SCL
Biochemical Society transactions 20191001 5
Structural and biochemical studies on diverse enzymes have highlighted the importance of ligand-gated conformational changes in enzyme catalysis, where the intrinsic binding energy of the common phosphoryl group of their substrates is used to drive energetically unfavorable conformational changes in catalytic loops, from inactive open to catalytically competent closed conformations. However, computational studies have historically been unable to capture the activating role of these conformationa ...[more]
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