Ontology highlight
ABSTRACT:
SUBMITTER: Bardoni R
PROVIDER: S-EPMC6825123 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Bardoni Rita R Shen Kai-Feng KF Li Hui H Jeffry Joseph J Barry Devin M DM Comitato Antonella A Li Yun-Qing YQ Chen Zhou-Feng ZF
Scientific reports 20191101 1
It has been known that algogens and cooling could inhibit itch sensation; however, the underlying molecular and neural mechanisms remain poorly understood. Here, we show that the spinal neurons expressing gastrin releasing peptide receptor (GRPR) primarily comprise excitatory interneurons that receive direct and indirect inputs from C and Aδ fibers and form contacts with projection neurons expressing the neurokinin 1 receptor (NK1R). Importantly, we show that noxious or cooling agents inhibit th ...[more]