Ontology highlight
ABSTRACT:
SUBMITTER: Liu MZ
PROVIDER: S-EPMC6936532 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Liu Ming-Zhe MZ Chen Xiao-Jun XJ Liang Tong-Yu TY Li Qing Q Wang Meng M Zhang Xin-Yan XY Li Yu-Zhuo YZ Sun Qiang Q Sun Yan-Gang YG
Proceedings of the National Academy of Sciences of the United States of America 20191205 52
Spinal gastrin-releasing peptide receptor-expressing (GRPR<sup>+</sup>) neurons play an essential role in itch signal processing. However, the circuit mechanisms underlying the modulation of spinal GRPR<sup>+</sup> neurons by direct local and long-range inhibitory inputs remain elusive. Using viral tracing and electrophysiological approaches, we dissected the neural circuits underlying the inhibitory control of spinal GRPR<sup>+</sup> neurons. We found that spinal galanin<sup>+</sup> GABAergic n ...[more]