Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki A
PROVIDER: S-EPMC6826039 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20191017 20
It has been long appreciated that sex hormone receptors are expressed in various non-gonadal organs. However, it remains unclear how sex hormones regulate the morphogenesis of these non-gonadal organs. To address this issue, we used a male mouse model of androgen-dependent salivary gland morphogenesis. Mice with excessive cholesterol synthesis in the salivary glands exhibited defects in the maturation of granular convoluted tubules (GCTs), which is regulated through sex hormone-dependent cascade ...[more]