Ontology highlight
ABSTRACT:
SUBMITTER: Jiang H
PROVIDER: S-EPMC6826206 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Jiang Hui H Xue Xiaoyu X Panda Swarupa S Kawale Ajinkya A Hooy Richard M RM Liang Fengshan F Sohn Jungsan J Sung Patrick P Gekara Nelson O NO
The EMBO journal 20190923 21
DNA repair via homologous recombination (HR) is indispensable for genome integrity and cell survival but if unrestrained can result in undesired chromosomal rearrangements. The regulatory mechanisms of HR are not fully understood. Cyclic GMP-AMP synthase (cGAS) is best known as a cytosolic innate immune sensor critical for the outcome of infections, inflammatory diseases, and cancer. Here, we report that cGAS is primarily a chromatin-bound protein that inhibits DNA repair by HR, thereby accelera ...[more]