Ontology highlight
ABSTRACT:
SUBMITTER: Ishikawa K
PROVIDER: S-EPMC6826312 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Ishikawa Kazuma K Kawano Yutaka Y Arihara Yohei Y Kubo Tomohiro T Takada Kohichi K Murase Kazuyuki K Miyanishi Koji K Kobune Masayoshi M Kato Junji J
Oncology reports 20191015 6
5‑Fluorouracil (5‑FU) is a cytotoxic anticancer drug commonly used for patients with advanced colon cancer. This drug effectively reduces the size of tumors to a certain degree; however, cancer cells can gradually acquire resistance, resulting in disease progression. To identify the mechanism of 5‑FU resistance, we established three 5‑FU‑resistant colon cancer cell lines and analyzed both apoptosis‑related protein expression levels and BH3 profiling. These 5‑FU‑resistant colon cancer cell lines ...[more]