Ontology highlight
ABSTRACT:
SUBMITTER: Riahi-Chebbi I
PROVIDER: S-EPMC6336835 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Riahi-Chebbi Ichrak I Souid Soumaya S Othman Houcemeddine H Haoues Meriam M Karoui Habib H Morel Alain A Srairi-Abid Najet N Essafi Makram M Essafi-Benkhadir Khadija K
Scientific reports 20190117 1
Resistance to 5-Fluorouracil chemotherapy is a major cause of therapeutic failure in colon cancer cure. Development of combined therapies constitutes an effective strategy to inhibit cancer cells and prevent the emergence of drug resistance. For this purpose, we investigated the anti-tumoral effect of thirteen phenolic compounds, from the Tunisian quince Cydonia oblonga Miller, alone or combined to 5-FU, on the human 5-FU-resistant LS174-R colon cancer cells in comparison to parental cells. Our ...[more]