Ontology highlight
ABSTRACT:
SUBMITTER: Shu K
PROVIDER: S-EPMC6826340 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
ACS combinatorial science 20180403 5
One-bead one-compound (OBOC) libraries constructed by solid-phase split-and-pool synthesis are a valuable source of protein ligands. Most OBOC libraries are composed of oligoamides, particularly peptides, peptoids, and peptoid-inspired molecules. Further diversification of the chemical space covered by OBOC libraries is desirable. Toward this end, we report here that the proline-catalyzed asymmetric aldol reaction, developed by List and Barbas for solution-phase synthesis, also works well for co ...[more]