Dataset Information

The association between self-reported poor oral health and gastrointestinal cancer risk in the UK Biobank: A large prospective cohort study.

ABSTRACT:

Background

Controversy remains as to whether poor oral health is independently associated with gastrointestinal cancers, due to potential confounding by smoking, alcohol and poor nutrition. The aim of this study was to investigate the association between oral health conditions and gastrointestinal cancer risk.

Methods

Data from the large, prospective UK Biobank cohort, which includes n?=?475,766 participants, were analysed. Cox proportional hazard models were applied to estimate the relationship between gastrointestinal cancer risk and self-reported poor oral health (defined as painful gums, bleeding gums and/or having loose teeth), adjusting for confounders.

Results

During an average six years of follow-up, n?=?4069 gastrointestinal cancer cases were detected, of which 13% self-reported poor oral health. Overall, there was no association between self-reported poor oral health and risk of gastrointestinal cancer detected (hazard ratio 0.97, 95% confidence interval 0.88-1.07). In site-specific analysis, an increased risk of hepatobiliary cancers was observed in those with self-reported poor oral health (hazard ratio 1.32, 95% confidence interval 0.95-1.80), which was stronger for hepatocellular carcinoma (hazard ratio 1.75, 95% confidence interval 1.04-2.92).

Conclusion

Overall there was no association between self-reported poor oral health and gastrointestinal cancer risk. However, there was a suggestion of an increased risk of hepatobiliary cancer, specifically hepatocellular carcinoma.

SUBMITTER: Jordao HW

PROVIDER: S-EPMC6826526 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Publications

The association between self-reported poor oral health and gastrointestinal cancer risk in the UK Biobank: A large prospective cohort study.

Jordão Haydée Wt HW McKenna Gerry G McMenamin Úna C ÚC Kunzmann Andrew T AT Murray Liam J LJ Coleman Helen G HG

United European gastroenterology journal 20190608 9

<h4>Background</h4>Controversy remains as to whether poor oral health is independently associated with gastrointestinal cancers, due to potential confounding by smoking, alcohol and poor nutrition. The aim of this study was to investigate the association between oral health conditions and gastrointestinal cancer risk.<h4>Methods</h4>Data from the large, prospective UK Biobank cohort, which includes <i>n</i> = 475,766 participants, were analysed. Cox proportional hazard models were applied to est ...[more]

PMID: 31700637

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Dataset Information

The association between self-reported poor oral health and gastrointestinal cancer risk in the UK Biobank: A large prospective cohort study.

Background

Methods

Results

Conclusion

Publications

The association between self-reported poor oral health and gastrointestinal cancer risk in the UK Biobank: A large prospective cohort study.

Similar Datasets

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