Exosomal microRNAs from Longitudinal Liquid Biopsies for the Prediction of Response to Induction Chemotherapy in High-Risk Neuroblastoma Patients: A Proof of Concept SIOPEN Study.
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ABSTRACT:
SUBMITTER: Morini M
PROVIDER: S-EPMC6826693 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Exosomal microRNAs from Longitudinal Liquid Biopsies for the Prediction of Response to Induction Chemotherapy in High-Risk Neuroblastoma Patients: A Proof of Concept SIOPEN Study.
Morini Martina M Cangelosi Davide D Segalerba Daniela D Marimpietri Danilo D Raggi Federica F Castellano Aurora A Fruci Doriana D de Mora Jaime Font JF Cañete Adela A Yáñez Yania Y Viprey Virginie V Corrias Maria Valeria MV Carlini Barbara B Pezzolo Annalisa A Schleiermacher Gudrun G Mazzocco Katia K Ladenstein Ruth R Sementa Angela Rita AR Conte Massimo M Garaventa Alberto A Burchill Susan S Luksch Roberto R Bosco Maria Carla MC Eva Alessandra A Varesio Luigi L
Cancers 20190930 10
Despite intensive treatment, 50% of children with high-risk neuroblastoma (HR-NB) succumb to their disease. Progression through current trials evaluating the efficacy of new treatments for children with HR disease usually depends on an inadequate response to induction chemotherapy, assessed using imaging modalities. In this study, we sought to identify circulating biomarkers that might be detected in a simple blood sample to predict patient response to induction chemotherapy. Since exosomes rele ...[more]
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