Ontology highlight
ABSTRACT:
SUBMITTER: Vitiello PP
PROVIDER: S-EPMC6827157 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Vitiello Pietro Paolo PP De Falco Vincenzo V Giunta Emilio Francesco EF Ciardiello Davide D Cardone Claudia C Vitale Pasquale P Zanaletti Nicoletta N Borrelli Carola C Poliero Luca L Terminiello Marinella M Arrichiello Gianluca G Caputo Vincenza V Famiglietti Vincenzo V Mattera Iacono Valentina V Marrone Francesca F Di Liello Alessandra A Martini Giulia G Napolitano Stefania S Caraglia Michele M Lombardi Angela A Franco Renato R De Vita Ferdinando F Morgillo Floriana F Troiani Teresa T Ciardiello Fortunato F Martinelli Erika E
Cancers 20191008 10
Tumor heterogeneity represents a possible cause of error in detecting predictive genetic alterations on tumor tissue and can be overcome by testing alterations in circulating tumor DNA (ctDNA) using liquid biopsy. We assessed 72 consecutive patients with a diagnosis of metastatic colorectal cancer (mCRC) using Idylla™ Biocartis, a fully automated platform that evaluates the most frequent mutations of KRAS, NRAS and BRAF genes. We correlated the results of liquid biopsy and standard tissue-based ...[more]