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Study in mCRC Patients RAS/BRAF wt Tissue and RAS Mutated LIquid BIopsy to Compare FOLFIRI Plus CetuxiMAb or BevacizumaB

ABSTRACT: This study is a prospective, randomized phase III, to evaluate if in patients with mCRC RAS/BRAF wild type on tumor tissue and RAS mutations on liquid biopsy, treating in first line with antibody anti-VEGF (bevacizumab) plus chemotherapy (FOLFIRI) is superior in terms of PFS compared to standard treatment with antibody anti-EGFR (cetuximab) plus FOLFIRI, and then in patients RAS/BRAF wild type on tumor tissue who develop RAS mutations on liquid biopsy after the beginning of the first line treatment with cetuximab plus FOLFIRI, in the absence of a clinical or radiological progression disease, to anticipate a change of treatment with bevacizumab plus FOLFIRI further impacts on the PFS.

DISEASE(S): Metastatic Colorectal Cancer,Patients With Metastatic Colorectal Cancer Ras/braf Wild Type Not Previously Treated In Metastatic Setting,Colorectal Neoplasms Malignant,Pazienti Con Tumore Del Colon-retto Metastatico (mcrc)ras/braf Wild Type Non Precedentemente Trattati Per Malattia Metastatica.,Colorectal Cancer,Gastrointestinal Disorders,Ras Mutation,Colorectal Neoplasms

PROVIDER: 2369067 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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