Ontology highlight
ABSTRACT:
SUBMITTER: Zhang M
PROVIDER: S-EPMC6828705 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Zhang Mengyi M Wang Baocheng B Chong Qing-Yun QY Pandey Vijay V Guo Zhirong Z Chen Ru-Mei RM Wang Lingzhi L Wang Yanxin Y Ma Lan L Kumar Alan P AP Zhu Tao T Wu Zheng-Sheng ZS Yin Zhinan Z Basappa Goh Boon-Cher BC Lobie Peter E PE
Oncogenesis 20191104 11
TFF3 has been identified as a novel biomarker to distinguish between lung adenocarcinoma (ADC) and lung squamous-cell carcinoma (SCC). Herein, we determined the oncogenic functions of TFF3 and demonstrated the potential of pharmacological inhibition of TFF3 in lung ADC using a novel small-molecule inhibitor of TFF3 dimerization (AMPC). Forced expression of TFF3 in lung ADC cells enhanced cell proliferation and survival, increased anchorage-independent growth, cancer stem cell behavior, growth in ...[more]