Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC6829372 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Wu Xinhui X van Dijk Eline M EM Ng-Blichfeldt John-Poul JP Bos I Sophie T IST Ciminieri Chiara C Königshoff Melanie M Kistemaker Loes E M LEM Gosens Reinoud R
Cells 20190925 10
Chronic obstructive pulmonary disease (COPD) represents a worldwide concern with high morbidity and mortality, and is believed to be associated with accelerated ageing of the lung. Alveolar abnormalities leading to emphysema are a key characteristic of COPD. Pulmonary alveolar epithelial type 2 cells (AT2) produce surfactant and function as progenitors for type 1 cells. Increasing evidence shows elevated WNT-5A/B expression in ageing and in COPD that may contribute to the disease process. Howeve ...[more]