Wnt-5A/B Signaling in Hematopoiesis throughout Life.
Ontology highlight
ABSTRACT:
SUBMITTER: Mastelaro de Rezende M
PROVIDER: S-EPMC7465103 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Wnt-5A/B Signaling in Hematopoiesis throughout Life.
Mastelaro de Rezende Marina M Zenker Justo Giselle G Julian Paredes-Gamero Edgar E Gosens Reinoud R
Cells 20200729 8
Wnt signaling is well-known to play major roles in the hematopoietic system, from embryogenesis to aging and disease. In addition to the main β-catenin-dependent pathway, it is now clear that Wnt5a and the structurally related Wnt5b are essential for hematopoiesis, bone marrow colonization and the final steps of hematopoietic stem cell (HSC) maturation via β-catenin-independent signaling. Wnt5a and Wnt5b ligands prevent hematopoietic exhaustion (by maintaining quiescent, long-term HSCs), induce ...[more]
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