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Fabrication and Characterization of Silk Fibroin/Curcumin Sustained-Release Film.

ABSTRACT: In the present work, a sustained-release film composed of silk fibroin (SF), curcumin (Cur), glutaraldehyde (GA), and glycerol (Gly) was prepared successfully for wound dressings. Features relevant to wound dressings of SF/Gly/GA/Cur film were assessed. Physical and chemical properties of the fabricated materials were also characterized. The results showed that the prepared SF/Gly/GA/Cur film demonstrated a good sustained-release performance, flexibility, and gas permeability. In addition, it was found that the prepared SF/Gly/GA/Cur film possessed the capability to effectively inhibit the growth of bacteria and prevent bacterial penetration with a suitable water vapor transmission rate. Furthermore, the prepared composite film was non-cytotoxic, which makes it an ideal material for wound dressings.

SUBMITTER: Zhang X

PROVIDER: S-EPMC6829413 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Fabrication and Characterization of Silk Fibroin/Curcumin Sustained-Release Film.

Zhang Xiaoning X Chen Zhenyu Z Bao Hong H Liang Jianwei J Xu Shui S Cheng Guotao G Zhu Yong Y

Materials (Basel, Switzerland) 20191014 20

In the present work, a sustained-release film composed of silk fibroin (SF), curcumin (Cur), glutaraldehyde (GA), and glycerol (Gly) was prepared successfully for wound dressings. Features relevant to wound dressings of SF/Gly/GA/Cur film were assessed. Physical and chemical properties of the fabricated materials were also characterized. The results showed that the prepared SF/Gly/GA/Cur film demonstrated a good sustained-release performance, flexibility, and gas permeability. In addition, it wa ...[more]

PMID: 31614998

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