Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Gomez H
PROVIDER: S-EPMC6829517 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Martin-Gómez Helena H Jorba Marta M Albericio Fernando F Viñas Miguel M Tulla-Puche Judit J
International journal of molecular sciences 20191017 20
In this study, microcin J25, a potent antimicrobial lasso peptide that acts on Gram-negative bacteria, was subjected to a harsh treatment with a base in order to interrogate its stability and mechanism of action and explore its structure-activity relationship. Despite the high stability reported for this lasso peptide, the chemical treatment led to the detection of a new product. Structural studies revealed that this product retained the lasso topology, but showed no antimicrobial activity due t ...[more]