Unknown

Dataset Information

0

The leucine-responsive regulatory protein, Lrp, modulates microcin J25 intrinsic resistance in Escherichia coli by regulating expression of the YojI microcin exporter.


ABSTRACT: Many Escherichia coli K-12 strains display an intrinsic resistance to the peptide antibiotic microcin J25. In this study, we present results showing that the leucine-responsive regulatory protein, Lrp, is involved in this phenotype by acting as a positive regulator of YojI, a chromosomally encoded efflux pump which expels microcin out of cells. Exogenous leucine antagonizes the effect of Lrp, leading to a diminished expression of the pump and an increased susceptibility to microcin J25.

SUBMITTER: Socias SB 

PROVIDER: S-EPMC2632010 | biostudies-other | 2009 Feb

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC4135631 | biostudies-literature
| S-EPMC150119 | biostudies-literature
| S-EPMC2614783 | biostudies-literature
| S-EPMC179537 | biostudies-other
| S-EPMC206857 | biostudies-other
| S-EPMC49059 | biostudies-other
| S-EPMC208338 | biostudies-other
| S-EPMC9831280 | biostudies-literature
| S-EPMC5320599 | biostudies-literature
| S-EPMC8082694 | biostudies-literature