Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen PM
PROVIDER: S-EPMC6829663 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Nguyen Phuoc My PM Gandasi Nikhil R NR Xie Beichen B Sugahara Sari S Xu Yingke Y Idevall-Hagren Olof O
The Journal of cell biology 20190918 11
Insulin granule biogenesis involves transport to, and stable docking at, the plasma membrane before priming and fusion. Defects in this pathway result in impaired insulin secretion and are a hallmark of type 2 diabetes. We now show that the phosphatidylinositol 4-phosphate phosphatase Sac2 localizes to insulin granules in a substrate-dependent manner and that loss of Sac2 results in impaired insulin secretion. Sac2 operates upstream of granule docking, since loss of Sac2 prevented granule tether ...[more]