Ontology highlight
ABSTRACT:
SUBMITTER: Engevik AC
PROVIDER: S-EPMC6829668 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Engevik Amy C AC Kaji Izumi I Postema Meagan M MM Faust James J JJ Meyer Anne R AR Williams Janice A JA Fitz Gillian N GN Tyska Matthew J MJ Wilson Jean M JM Goldenring James R JR
The Journal of cell biology 20190927 11
In patients with inactivating mutations in myosin Vb (Myo5B), enterocytes show large inclusions lined by microvilli. The origin of inclusions in small-intestinal enterocytes in microvillus inclusion disease is currently unclear. We postulated that inclusions in Myo5b KO mouse enterocytes form through invagination of the apical brush border membrane. 70-kD FITC-dextran added apically to Myo5b KO intestinal explants accumulated in intracellular inclusions. Live imaging of Myo5b KO-derived enteroid ...[more]