Ontology highlight
ABSTRACT:
SUBMITTER: Hemric BN
PROVIDER: S-EPMC6830571 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
ACS catalysis 20190924 11
A three-component reaction for 1,2-amino oxygenation of 1,3-dienes has been achieved using <i>O</i>-acyl hydroxylamines and carboxylic acids. The reaction occurs through copper-catalyzed amination of olefins followed by nucleophilic addition of carboxylic acids, offering high levels of chemo-, regio-, and site-selectivity. The method is effective for both terminal and internal 1,3-dienes, including those bearing multiple, unsymmetrical substituents. The amino oxygenation conditions also exhibite ...[more]