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Relationships between dipstick proteinuria and risk of hearing impairment among Japanese workers: a prospective cohort study.

ABSTRACT: OBJECTIVES:Hearing impairment is among the most significant health problems, and the number of adults with hearing impairment is increasing worldwide. Therefore, the prevention of hearing impairment is important. Proteinuria appears to be a risk factor for hearing impairment, but no prospective studies have examined the association between proteinuria and hearing impairment risk. This prospective study aimed to clarify the association between dipstick proteinuria and risk of hearing impairment. DESIGN:This was a prospective cohort study based on annual health check-up data, 2008-2016. SETTING:Data were collected on 7005 employees of a single company who worked in offices and factories throughout Japan. PARTICIPANTS:We analysed data from 5699 subjects (88.6% men) who underwent annual health check-ups twice or more from 2008 to 2016, had no missing data, and were free from hearing impairment at baseline. We regarded the first health check-up as the baseline examination. PRIMARY AND SECONDARY OUTCOME MEASURES:Hearing tests were performed using audiometry at two frequencies (1 and 4?kHz) during the health check-ups. Defining total moderate hearing impairment as the inability to respond to 30?dB at 1?kHz and/or 40?dB at 4?kHz, we examined the association between dipstick proteinuria at baseline and risk of hearing impairment at final examination. RESULTS:Total moderate hearing impairment was noted in 162 (2.8%) subjects. Compared with subjects without proteinuria at baseline, the multivariable adjusted OR (95% CI) was 5.35 (1.87-15.25) for subjects with proteinuria ?2+, 0.92 (0.40-2.13) for those with proteinuria +/-, and 1.33 (0.63-2.80) for those with proteinuria+ at baseline. CONCLUSIONS:Severe dipstick proteinuria was positively associated with risk of hearing impairment in the future. Our results suggest that medical examinations including urine testing are effective for detecting subjects with high risk of hearing impairment.

SUBMITTER: Umesawa M

PROVIDER: S-EPMC6830626 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Relationships between dipstick proteinuria and risk of hearing impairment among Japanese workers: a prospective cohort study.

Umesawa Mitsumasa M Hara Mikako M Sairenchi Toshimi T Nagao Masanori M Haruyama Yasuo Y Kobashi Gen G

BMJ open 20191102 11

<h4>Objectives</h4>Hearing impairment is among the most significant health problems, and the number of adults with hearing impairment is increasing worldwide. Therefore, the prevention of hearing impairment is important. Proteinuria appears to be a risk factor for hearing impairment, but no prospective studies have examined the association between proteinuria and hearing impairment risk. This prospective study aimed to clarify the association between dipstick proteinuria and risk of hearing impa ...[more]

PMID: 31678936

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Project description:BACKGROUND:Aging process is accompanied by a chronic sub-clinical systemic inflammation. This study aimed to assess the association between hearing impairment and polymorphisms of genes encoding cytokines deeply-committed to the inflammatory response and immune homeostasis in an elderly Japanese population. Data were collected in the Longitudinal Study of Aging surveyed biennially between 1997 and 2010. The participants without any missing information at baseline were 1,957 individuals, and the gross accumulated number of 8,675 subjects (40-89 years of age) was analyzed. Two hearing impairment criteria were taken as the better ear pure-tone average (PTABE) greater than 25 dB and greater than 40 dB. We analyzed cumulative data using generalized estimating equations to investigate the effect of 9 polymorphisms, namely, tumor necrosis factor (TNF) ?, rs1800630; TNF receptor super family (TNFRSF) 1B, rs1061624; interleukin (IL)-1A, rs1800587; IL-1B, rs16944; IL-4R, rs1801275; IL-6, rs1800796; IL-10, rs1800872; IL-1 receptor-associated kinase 1 (IRAK1), rs1059702; C reactive protein (CRP), rs1130864. RESULTS:The odds ratios for the hearing impairment (PTABE >25 dB) risk under additive genetic model were significant in TNF-? rs1800630 and TNFRSF1B rs1061624, which were respectively 1.172 (confidence interval [CI]: 1.005-1.367), 1.211 (CI: 1.053-1.392) in model after adjustment for possible confounders. Using the criterion of PTABE >40 dB as disabling hearing impairment, the association remains significant in TNFRSF1B rs1061624, but not in TNF-? rs1800630. No other polymorphisms showed a significant association. CONCLUSIONS:The present population-based cohort study demonstrated that TNF-? rs1800630 and TNFRSF1B rs1061624 contributed to the incremental risk of hearing impairment in the elderly. TNF-? and TNF receptor interactions play a pivotal role in the pathogenesis of the inflammatory response, and also cause programmed cell death and cell proliferation. The present observation implied the signalling cascades of TNF were involved in ear aging.

Dataset Information

Relationships between dipstick proteinuria and risk of hearing impairment among Japanese workers: a prospective cohort study.

Publications

Relationships between dipstick proteinuria and risk of hearing impairment among Japanese workers: a prospective cohort study.

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