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Kinetic studies on clinical and immunological modulations by intramuscular injection of Escherichia coli LPS in laying hens.


ABSTRACT: The present study investigated clinical and immunological modulations due to intramuscular injection of Escherichia coli LPS in 49-wk-old laying hens over 48 h post injection (p.i.). LPS induced characteristic sickness behavior but no significant body temperature alterations ( P?>?0.05). During experimental period decreases in blood albumin, calcium, phosphorus and tryptophan concentrations, hyperglycemia, increased plasma nitrite concentrations, leucopenia, decreased thrombocyte counts, lymphopenia, heterophilia and an increased heterophilic granulocyte/lymphocyte (H/L) ratio were observed after LPS administration. Time-dependent effects were shown on T and B cell subsets in caecal tonsils (CT) and on splenic CD3+/CD4+/CD8+ proportions, on IL-1? and -10 and inducible NO synthase mRNA expression in peripheral blood lymphocytes (PBL), liver, spleen and CT, and on the mRNA expression of the TLR4 in PBL, liver and spleen p.i. ( P?

SUBMITTER: Liermann W 

PROVIDER: S-EPMC6830938 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Kinetic studies on clinical and immunological modulations by intramuscular injection of Escherichia coli LPS in laying hens.

Liermann Wendy W   Frahm Jana J   Halle Ingrid I   Bühler Susanne S   Kluess Jeannette J   Hüther Liane L   Dänicke Sven S  

Innate immunity 20190401 3


The present study investigated clinical and immunological modulations due to intramuscular injection of Escherichia coli LPS in 49-wk-old laying hens over 48 h post injection (p.i.). LPS induced characteristic sickness behavior but no significant body temperature alterations ( P > 0.05). During experimental period decreases in blood albumin, calcium, phosphorus and tryptophan concentrations, hyperglycemia, increased plasma nitrite concentrations, leucopenia, decreased thrombocyte counts, lymphop  ...[more]

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