Ontology highlight
ABSTRACT:
SUBMITTER: Enomoto A
PROVIDER: S-EPMC6831656 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Enomoto Atsushi A Fukasawa Takemichi T Tsumoto Hiroki H Karube Masataka M Nakagawa Keiichi K Yoshizaki Ayumi A Sato Shinichi S Miura Yuri Y Miyagawa Kiyoshi K
Scientific reports 20191105 1
Serine-threonine kinase 38 (STK38) is a member of the protein kinase A (PKA)/PKG/PKC-family implicated in the regulation of cell division and morphogenesis. However, the molecular mechanisms underlying STK38 stability remain largely unknown. Here, we show that treatment of cells with either heat or the calcium ionophore A23187 induced STK38 degradation. The calpain inhibitor calpeptin suppressed hyperthermia-induced degradation or the appearance of A23187-induced cleaved form of STK38. An in vit ...[more]