Ontology highlight
ABSTRACT:
SUBMITTER: Deng B
PROVIDER: S-EPMC6832013 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
EMBO reports 20190905 11
LTR retrotransposons are abundant repetitive elements in the human genome, but their functions remain poorly understood. Here, we report the function and regulatory mechanism of an ERV-9 LTR retrotransposon-derived lncRNA called p53-regulated lncRNA for homologous recombination (HR) repair 1 (PRLH1) in human cells. PRLH1 is highly expressed in p53-mutated hepatocellular carcinoma (HCC) samples and promotes cell proliferation in p53-mutated HCC cells, and its transcription is promoted by NF-Y and ...[more]