Association between CSF1 and CSF1R Polymorphisms and Parkinson's Disease in Taiwan.
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ABSTRACT:
SUBMITTER: Chang KH
PROVIDER: S-EPMC6832167 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Association between CSF1 and CSF1R Polymorphisms and Parkinson's Disease in Taiwan.
Chang Kuo-Hsuan KH Wu Yih-Ru YR Chen Yi-Chun YC Wu Hsiu-Chuan HC Chen Chiung-Mei CM
Journal of clinical medicine 20190924 10
<h4>Background</h4>CSF1/CSF1R neuroinflammatory signaling is emerging as an important pathway involved in the pathogenesis of Parkinson's disease (PD). However, the genetic associations between <i>CSF1</i>/<i>CSF1R</i> and PD have not yet been explored.<h4>Methods</h4>We investigated the effects of two functional genetic variants, including <i>CSF1</i> rs1058885 and <i>CSF1R</i> rs10079250 in a cohort including 502 Taiwanese patients with PD and 511 age- and gender-matched healthy controls.<h4>R ...[more]
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Project description:Previous genome-wide association studies in Caucasian populations suggest that genetic loci in amino acid catabolism may be associated with Parkinson's disease (PD). However, these genetic disease associations were limitedly reported in Asian populations. Herein, we investigated the effect of top three PD-associated genetic variants related to amino acid catabolism in Caucasians listed on the top risk loci identified by meta-analysis of genome-wide association studies in PDGene database, including aminocarboxymuconate-semialdehyde decarboxylase- (ACMSD-) transmembrane protein 163 (TMEM163) rs6430538, methylcrotonyl-CoA carboxylase 1 (MCCC1) rs12637471, and branched-chain ketoacid dehydrogenase kinase- (BCKDK-) syntaxin 1B (STX1B) rs14235, by genotyping 599 Taiwanese patients with PD and 598 age-matched control subjects. PD patients demonstrate similar allelic and genotypic frequencies in all tested genetic variants. These ethnic discrepancies of genetic variants suggest a distinct genetic background of amino acid catabolism between Taiwanese and Caucasian PD patients.
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