Ontology highlight
ABSTRACT:
SUBMITTER: Tan A
PROVIDER: S-EPMC6832257 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Tan Aaron A Babak Maria V MV Venkatesan Gopalakrishnan G Lim Clarissa C Klotz Karl-Norbert KN Herr Deron Raymond DR Cheong Siew Lee SL Federico Stephanie S Spalluto Giampiero G Ong Wei-Yi WY Chen Yu Zong YZ Loo Jason Siau Ee JSE Pastorin Giorgia G
Molecules (Basel, Switzerland) 20191011 20
Human A<sub>3</sub> adenosine receptor hA<sub>3</sub>AR has been implicated in gastrointestinal cancer, where its cellular expression has been found increased, thus suggesting its potential as a molecular target for novel anticancer compounds. Observation made in our previous work indicated the importance of the carbonyl group of amide in the indolylpyrimidylpiperazine (IPP) for its human A<sub>2A</sub> adenosine receptor (hA<sub>2A</sub>AR) subtype binding selectivity over the other AR subtypes ...[more]