Dataset Information

Density Structure of the Von Karman Crater in the Northwestern South Pole-Aitken Basin: Initial Subsurface Interpretation of the Chang'E-4 Landing Site Region.

ABSTRACT: The Von Kármán Crater, within the South Pole-Aitken (SPA) Basin, is the landing site of China's Chang'E-4 mission. To complement the in situ exploration mission and provide initial subsurface interpretation, we applied a 3D density inversion using the Gravity Recovery and Interior Laboratory (GRAIL) gravity data. We constrain our inversion method using known geological and geophysical lunar parameters to reduce the non-uniqueness associated with gravity inversion. The 3D density models reveal vertical and lateral density variations, 2600-3200 kg/m3, assigned to the changing porosity beneath the Von Kármán Crater. We also identify two mass excess anomalies in the crust with a steep density contrast of 150 kg/m3, which were suggested to have been caused by multiple impact cratering. The anomalies from recovered near surface density models, together with the gravity derivative maps extending to the lower crust, are consistent with surface geological manifestation of excavated mantle materials from remote sensing studies. Therefore, we suggest that the density distribution of the Von Kármán Crater indicates multiple episodes of impact cratering that resulted in formation and destruction of ancient craters, with crustal reworking and excavation of mantle materials.

SUBMITTER: Chisenga C

PROVIDER: S-EPMC6832371 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Density Structure of the Von Kármán Crater in the Northwestern South Pole-Aitken Basin: Initial Subsurface Interpretation of the Chang'E-4 Landing Site Region.

Chisenga Chikondi C Yan Jianguo J Zhao Jiannan J Deng Qingyun Q Barriot Jean-Pierre JP

Sensors (Basel, Switzerland) 20191014 20

The Von Kármán Crater, within the South Pole-Aitken (SPA) Basin, is the landing site of China's Chang'E-4 mission. To complement the in situ exploration mission and provide initial subsurface interpretation, we applied a 3D density inversion using the Gravity Recovery and Interior Laboratory (GRAIL) gravity data. We constrain our inversion method using known geological and geophysical lunar parameters to reduce the non-uniqueness associated with gravity inversion. The 3D density models reveal ve ...[more]

PMID: 31615029

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Project description:Pathogenic somatic missense mutations within the DNA polymerase epsilon (POLE) exonuclease domain define the important subtype of ultramutated tumours ('POLE-ultramutated') within the novel molecular classification of endometrial carcinoma (EC). However, clinical implementation of this classifier requires systematic evaluation of the pathogenicity of POLE mutations. To address this, we examined base changes, tumour mutational burden (TMB), DNA microsatellite instability (MSI) status, POLE variant frequency, and the results from six in silico tools on 82 ECs with whole-exome sequencing from The Cancer Genome Atlas (TCGA). Of these, 41 had one of five known pathogenic POLE exonuclease domain mutations (EDM) and showed characteristic genomic alterations: C>A substitution > 20%, T>G substitutions > 4%, C>G substitutions < 0.6%, indels < 5%, TMB > 100 mut/Mb. A scoring system to assess these alterations (POLE-score) was developed; based on their scores, 7/18 (39%) additional tumours with EDM were classified as POLE-ultramutated ECs, and the six POLE mutations present in these tumours were considered pathogenic. Only 1/23 (4%) tumours with non-EDM showed these genomic alterations, indicating that a large majority of mutations outside the exonuclease domain are not pathogenic. The infrequent combination of MSI-H with POLE EDM led us to investigate the clinical significance of this association. Tumours with pathogenic POLE EDM co-existent with MSI-H showed genomic alterations characteristic of POLE-ultramutated ECs. In a pooled analysis of 3361 ECs, 13 ECs with DNA mismatch repair deficiency (MMRd)/MSI-H and a pathogenic POLE EDM had a 5-year recurrence-free survival (RFS) of 92.3%, comparable to previously reported POLE-ultramutated ECs. Additionally, 14 cases with non-pathogenic POLE EDM and MMRd/MSI-H had a 5-year RFS of 76.2%, similar to MMRd/MSI-H, POLE wild-type ECs, suggesting that these should be categorised as MMRd, rather than POLE-ultramutated ECs for prognostication. This work provides guidance on classification of ECs with POLE mutations, facilitating implementation of POLE testing in routine clinical care. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

Dataset Information

Density Structure of the Von Karman Crater in the Northwestern South Pole-Aitken Basin: Initial Subsurface Interpretation of the Chang'E-4 Landing Site Region.

Publications

Density Structure of the Von Kármán Crater in the Northwestern South Pole-Aitken Basin: Initial Subsurface Interpretation of the Chang'E-4 Landing Site Region.

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